Maternal Neutralizing Antibody and Transmission of Hepatitis C Virus to Infants

Year: 2008

Type: article

Abstract: To determine whether lower levels of hepatitis C virus (HCV)-specific neutralizing antibodies (nAb) are associated with an increased risk of mother-to-child transmission (MTCT) of HCV, HCV nAb titers were assessed in 63 mothers coinfected with HCV and human immunodeficiency virus (HIV) type 1. Of the mothers, 16 transmitted HCV to their infant, but no difference was detected between the ability of maternal plasma from transmitters and nontransmitters to neutralize heterologous HCV pseudoparticles (median nAb titer, 1:125 vs. 1:100; P = .23). In the setting of HIV/HCV coinfection, we found no evidence that HCV nAbs are associated with the prevention of MTCT of HCV.

Source: The Journal of Infectious Diseases

DOI: 10.1086/593067

Authors: Kimberly A. Dowd, Ronald C. Hershow, Sigal Yawetz, Philip LaRussa, Clemente Diaz, Sheldon H. Landesman, Mary E. Paul, Jennifer S. Read, Ming Lu, David L. Thomas, Dale M. Netski, Stuart C. Ray

Institutions: Johns Hopkins University, Johns Hopkins Medicine, University of Illinois Chicago, Brigham and Women's Hospital, Harvard University, Columbia University, University of Puerto Rico System, Brookdale University Hospital and Medical Center, Baylor College of Medicine, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Language: English

Topic: Hepatitis C virus research

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development

OpenAlex ID: W2135747306