Year: 2014
Type: article
Study design: Observational Study
Abstract: BACKGROUND: In an era of expanded treatment options for severe aortic stenosis, it is important to understand risk factors for the condition. It has been suggested that severe aortic stenosis is less common in African Americans, but there are limited data from large studies. METHODS AND RESULTS: The Synthetic Derivative at Vanderbilt University Medical Center, a database of over 2.1 million de-identified patient records, was used to identify individuals who had undergone echocardiography. The association of race with severe aortic stenosis was examined using multivariable logistic regression analyses adjusting for conventional risk factors. Of the 272 429 eligible patients (mean age 45 years, 44% male) with echocardiography, 14% were African American and 82% were Caucasian. Severe aortic stenosis was identified in 106 (0.29%) African-American patients and 2030 (0.91%) Caucasian patients (crude OR 0.32, 95% CI [0.26, 0.38]). This difference persisted in multivariable-adjusted analyses (OR 0.41 [0.33, 0.50], P<0.0001). African-American individuals were also less likely to have severe aortic stenosis due to degenerative calcific disease (adjusted OR 0.47 [0.36, 0.61]) or congenitally bicuspid valve (crude OR 0.13 [0.02, 0.80], adjusted OR dependent on age). Referral bias against those with severe valvular disease was assessed by comparing the prevalence of severe mitral regurgitation in Caucasians and African Americans and no difference was found. CONCLUSIONS: These findings suggest that African Americans are at significantly lower risk of developing severe aortic stenosis than Caucasians.
Institution: Vanderbilt University Medical Center
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,810
Funders: Vanderbilt University, Vanderbilt University Medical Center, Georgia Clinical and Translational Science Alliance, National Institutes of Health, U.S. Public Health Service, National Heart, Lung, and Blood Institute, National Center for Advancing Translational Sciences, Core Research for Evolutional Science and Technology
OpenAlex ID: W2135854379