Work

Sequential blockade and engagement of costimulatory pathways: A potential strategy for amplifying graft-versus-leukemia responses without graft-versus-host disease

Year: 2005

Type: article

Abstract: One potential approach for the effective disengagement of graft-versus-leukemia (GVL) effects from graft-versus-host disease (GVHD) after bone marrow transplantation (BMT) is the use of nonmyeloablative (NM) conditioning to induce mixed chimerism as a platform for the delayed transfer of donor T cells. In preclinical models, CD8+ T cells derived from donor leucocyte infusions (DLIs) can induce powerful responses against tumors of host origin, but the effect lacks durability such that a rechallenge with tumor inevitability leads to tumor progression and death.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2004.12.028

Authors: R. Chakraverty, J. Buchli, G. Zhao, R. Hsu, M. Croft, M. Sykes

Institutions: Massachusetts General Hospital, La Jolla Institute for Immunology

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650