Work

An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin

Year: 2012

Type: article

Abstract: We describe the synthesis of a fluorescent deoxyguanosine derivative that co-assembles (in water) with an unlabeled analogue into a heteromeric supramolecular G-quadruplex, which forms a host-guest complex with doxorubicin as evidenced by FRET experiments.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/c2ob25913c

Authors: José M. Rivera, Mariana Martín-Hidalgo, Jean C. Rivera-Ríos

Institution: University of Puerto Rico at Río Piedras

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: Small Molecule Self-Assembly in Aqueos Media, MAXIMIZING THE QUALITY OF FUTURE GRADUATE STUDIES FOR UPR-RIO PIEDRAS MARC U*STAR TRAINEES, Support for University Biomedical Excellence at UPR-RP