Work

Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals

Year: 2011

Type: article

Abstract: Synthetic associations have been posited as a possible explanation for missing heritability in complex disease. We show several lines of evidence which suggest that, while possible, these synthetic associations are not common.

Source: PLoS Biology

DOI: 10.1371/journal.pbio.1000580

Authors: Carl A. Anderson, Nicole Soranzo, Eleftheria Zeggini, Jeffrey C. Barrett

Institution: Wellcome Sanger Institute

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,500

Funder: Wellcome Trust

Awards: G2100241283, G7596374027

OpenAlex ID: W2136173868

FWCI: 11.04

Cites: 32

Cited by: 110

Related to: 10