Year: 2012
Type: article
Abstract: Statins are the most widely prescribed class of drugs worldwide, \nand also the most powerful cholesterol-lowering drugs currently \navailable. Statins inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme \nA (HMG CoA) reductase, which leads to reduced cholesterol \nsynthesis. In addition, low-density cholesterol receptors on the \nhepatocyte surface are upregulated, leading to increased clearance \nof cholesterol. Cholesterol levels are reduced, which leads to a \nsignificant reduction in cardiovascular events, of 25-45%.
Author: James A. Ker
Institution: University of Pretoria
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2136187371