Work

A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus.

Year: 1989

Type: article

Abstract: In vitro infection by the human immunodeficiency virus (HIV) of CD4+ H9 lymphoblasts is inhibited by a mannose-binding protein (MBP) purified from human serum. In addition, MBP is able to selectively bind to HIV-infected H9 cells and HIV-infected cells from the monocyte cell line U937. These results indicate MBP most likely recognizes high mannose glycans known to be present on gp120 in the domain that is recognized by CD4 and thereby inhibits viral entry to susceptible cells. In support of this contention, recombinant gp120 binds directly to MBP; the binding is saturable, mannan inhibitable, removed by N-glycanase treatment, and dependent on divalent cations.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.169.1.185

Authors: R A Ezekowitz, M Kuhlman, J E Groopman, R A Byrn

Institution: Harvard University

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Genentech, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases