Get started
Work

Optimal Codon Choice Can Improve the Efficiency and Fidelity of N‐Methyl Amino Acid Incorporation into Peptides by In‐Vitro Translation

Year: 2011
Type: article
Abstract: May the best codon win: N-methyl amino acids (N-Me AAs) are important modifications found in several nonribosomal peptide therapeutics. Previously, it was shown that three N-Me AAs are efficiently incorporated into peptides using a cell-free in-vitro translation system. Now, the incorporation of these N-Me AAs has been optimized by varying the template codon.
DOI: 10.1002/anie.201007686
Institutions: Howard Hughes Medical Institute, Massachusetts General Hospital, Center for Computational and Integrative Biology, Massachusetts General Hospital, Massachusetts Institute of Technology, Virginia Commonwealth University, VCU Massey Comprehensive Cancer Center
Language: English
Open Access status: green
OpenAlex ID: W2136256341
FWCI: 0.975
Cites: 20
Cited by: 19
Related to: 10