Work

Immunogenetics of Spontaneous Control of HIV

Year: 2010

Type: review

Abstract: Host genetic variation is presently estimated to account for about one-fourth of the observed differences in control of HIV across infected individuals. Genome-wide association studies have confirmed that polymorphism within the HLA class I locus is the primary host genetic contributor to determining outcome after infection. Here we progress beyond the genetic associations alone to consider the functional explanations for these correlations. In this process, the complex and multidimensional effects of HLA molecules in viral disease become apparent.

Source: Annual Review of Medicine

DOI: 10.1146/annurev-med-062909-130018

Authors: Mary Carrington, Bruce D. Walker

Institutions: Ragon Institute of MGH, MIT and Harvard, Frederick National Laboratory for Cancer Research, National Cancer Institute, Massachusetts Institute of Technology, Science Applications International Corporation (United States)

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Bill and Melinda Gates Foundation, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases