Acute attack of AIP (acute intermittent porphyria) with severe vivax malaria associated with convulsions: a case report.
Year: 2009
Type: article
Study design: Case Report
Abstract: Key words Acute intermittent porphyria – convulsions – malaria – Plasmodium vivax Acute intermittent porphyria (AIP) is a hereditary hepatic porphyria inherited as autosomal dominant with low penetrance resulting from mutation in the gene encoding the enzyme, porphobilinogen deami-nase (PBG-D) [hydroxymethylbilane synthase, uroporphyrinogen I synthase]. The diagnosis is of-ten obscured by the variable presentation, viz. ab-dominal pain (commonest), constipation, vomiting, convulsions, and peripheral neuropathy and further complicated by the variable course of illness. Inci-dence of convulsions is 10–20 % but there may be presenting symptom of an acute relapse1,2. Although Plasmodium vivax usually causes benign uncompli-cated malaria, it can occasionally result in severe dis-
Source: PubMed
Authors: Sanjay K Kochar, Manish Mahajan, Rajendra P Gupta, Sheetal Middha, Jyoti Acharya, Abhishek Kochar, Ashis Das, Dhanpat K Kochar
Institution: Sardar Patel Medical College
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2136289540