Testing Predictions of the Oxidative Stress Hypothesis of Aging Using a Novel Invertebrate Model of Longevity: The Giant Clam (Tridacna Derasa)
Year: 2012
Type: article
Abstract: Bivalve species with exceptional longevity are newly introduced model systems in biogerontology to test evolutionarily conserved mechanisms of aging. Here, we tested predictions based on the oxidative stress hypothesis of aging using one of the tropical long-lived sessile giant clam species, the smooth giant clam (Tridacna derasa; predicted maximum life span: >100 years) and the short-lived Atlantic bay scallop (Argopecten irradians irradians; maximum life span: 2 years). The warm water-dwelling giant clams warrant attention because they challenge the commonly held view that the exceptional longevity of bivalves is a consequence of the cold water they reside in. No significant interspecific differences in production of H2O2 and O2- in the gills, heart, or adductor muscle were observed. Protein carbonyl content in gill and muscle tissues were similar in T derasa and A i irradians. In tissues of T derasa, neither basal antioxidant capacities nor superoxide dismutase and catalase activities were consistently greater than in A i irradians. We observed a positive association between longevity and resistance to mortality induced by exposure to tert-butyl hydroperoxide (TBHP). This finding is consistent with the prediction based on the oxidative stress hypothesis of aging. The findings that in tissues of T derasa, proteasome activities are significantly increased as compared with those in tissues of A i irradians warrant further studies to test the role of enhanced protein recycling activities in longevity of bivalves.
Authors: Z. Ungvari, A. Csiszar, D. Sosnowska, E. E. Philipp, C. M. Campbell, P. R. McQuary, T. T. Chow, M. Coelho, E. S. Didier, S. Gelino, M. A. Holmbeck, I. Kim, E. Levy, W. E. Sonntag, P. W. Whitby, S. N. Austad, I. Ridgway
Institutions: University of Oklahoma Health Sciences Center, University of Oklahoma, Christian-Albrechts-Universität zu Kiel, Vanderbilt University, Sanford Burnham Prebys Medical Discovery Institute, The University of Texas Southwestern Medical Center, Max Planck Institute of Molecular Cell Biology and Genetics, Tulane University, Brown University, Children's Hospital of Philadelphia, University of Pennsylvania, The University of Texas at San Antonio Health Science Center, Bangor University
Language: English
Subfield: Aging
Domain: Life Sciences
SDG: Life below water
Open Access status: green
Awards: G1583363307, Effects of Radiation on Brain Microvasculature and Cognition, G265137968, G3139818032, San Antonio Comparative Biology of Aging Center, G3706213990, Comparative Mechanisms of Exceptionally Slow Aging, G4406129823, G486904229, G5067898320, Mechanism of Atrial Fibrillation Susceptibility Due to Mutant Potassium Channels, G760902603, Vasoprotection by Caloric Restriction Mimetics in Aging, G8323086312, Growth Hormone & IGF-1 in CNS and Cerebrovascular Aging, NOVEL APPROACHES FOR REGULATION OF IGF-1 LEVELS THROUGHOUT THE LIFESPAN
OpenAlex ID: W2136368539