P1‐148: A tensor based morphometry study of patients with cognitive impairment and dementia in parkinson's disease
Year: 2009
Type: article
Study design: Observational Study
Abstract: Cognitive impairment is exceedingly common among patients with Parkinson's disease (PD), and a variety of cognitive domains are impaired early in PD. Both mild cognitive impairment (PDMCI) and dementia (PDD) are associated with PD. The brain changes accompanying cognitive decline in PD are still not fully established. We applied tensor based morphometry (TBM) to 3D T1-weighted MRI scans of 20 age-matched cognitively normal elderly (NC), 9 cognitively normal PD (PDND), 6 PDMCI, and 15 PDD subjects. We warped each individual image to the unbiased geometrical NC average template and created Jacobian maps showing the expansion or compression factor at each image point and statistical maps of between-group differences. Like voxel-based morphometry (VBM), TBM detects volumetric differences throughout the brain revealing 3D profiles of tissue excess or loss, creating statistical p maps. Relative to NC, PDD subjects showed significant atrophy (p<0.01) bilaterally in frontopolar and temporo-occipital areas; on the right in the posterior medial frontal, lateral medial temporal, lateral parieto-occipital and precuneal areas and on the left in the inferior and middle temporal areas. Relative to NC, PDMCI subjects showed significant atrophy (p<0.01) in the left pregenual cingulate, right frontopolar, and precuneal, and bilaterally in the medial temporal areas. Relative to NC, in the PDND group only a few areas of significant tissue loss (p<0.01) were found on the right side in the parahippocampal gyrus/medial temporal lobe, lateral medial temporal, medial frontal and postcentral areas. Cognitive decline in PD is associated with tissue loss. PDD subjects show detectable atrophy in more areas of the brain than PDMCI subjects. Cognitive decline in PD seems to be associated with medial and lateral frontal, medial and inferior temporal, precuneal and parietal atrophy. The dementia profile of PDD is characterised by executive, visuospatial and attentional impairment. This corresponds well with the areas of tissue loss shown in this study.
Source: Alzheimer s & Dementia
Authors: Po H. Lu, Liana G. Apostolova, Amity E. Green, Kristy Hwang, Christine Chung, Paul M. Thompson, Alex Leow, Grace Lee, Carmen C. Janvin, Jan P. Larsen, Jeffrey L. Cummings, Dag Aarsland, Mona K. Beyer
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2136371249