Work

Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression

Year: 2001

Type: article

Abstract: We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.

Source: Breast Cancer Research

DOI: 10.1186/bcr294

Authors: Kanokwan Kittiniyom, Karen M Gorse, Fabienne Dalbegue, Jack H Lichy, Jeffery K Taubenberger, Irene F Newsham

Institutions: Virginia Commonwealth University, Armed Forces Institute of Pathology

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,190