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Variation at the capsule locus, cps, of mistyped and non-typable Streptococcus pneumoniae isolates

Year: 2012
Type: article
Abstract: The capsule polysaccharide locus (cps) is the site of the capsule biosynthesis gene cluster in encapsulated Streptococcus pneumoniae. A set of pneumococcal samples and non-pneumococcal streptococci from Denmark, the Gambia, the Netherlands, Thailand, the UK and the USA were sequenced at the cps locus to elucidate serologically mistyped or non-typable isolates. We identified a novel serotype 33B/33C mosaic capsule cluster and previously unseen serotype 22F capsule genes, disrupted and deleted cps clusters, the presence of aliB and nspA genes that are unrelated to capsule production, and similar genes in the non-pneumococcal samples. These data provide greater understanding of diversity at a locus which is crucial to the antigenic diversity of the pathogen and current vaccine strategies.
Source: Microbiology
DOI: 10.1099/mic.0.056580-0
Authors: S. J. Salter, J. Hinds, K. A. Gould, L. Lambertsen, W. P. Hanage, M. Antonio, P. Turner, P. W. M. Hermans, H. J. Bootsma, K. L. O'Brien, S. D. Bentley
Institutions: Wellcome Sanger Institute, St George's, University of London, Statens Serum Institut, Harvard University, University of Oxford, Shoklo Malaria Research Unit, Radboud University Medical Center, Johns Hopkins University
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: green
OpenAlex ID: W2136396527
FWCI: 5.165
Cites: 50
Cited by: 77
Related to: 10