Work

Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features

Year: 2011

Type: article

Abstract: Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation. One of the main drugs associated with GO is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. Nevertheless, the pathogenesis of such drug-induced GO remains fulfilled by some contradictory findings. This paper aims to present the most relevant studies regarding the molecular, immune, and inflammatory aspects of phenytoin-induced gingival overgrowth.

Source: ISRN Dentistry

DOI: 10.5402/2011/497850

Authors: Jôice Dias Corrêa, Celso Martins Queiroz-Junior, José Eustáquio Costa, Antônio Lúcio Teixeira, Tarcilia Aparecida Silva

Institution: Universidade Federal de Minas Gerais

Language: English

Topic: Oral and gingival health research

Subfield: Pharmacy

Field: Health Professions

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Universidade Federal de Minas Gerais