Work

Switching the Targeting Pathways of a Therapeutic Antibody by Nanodesign

Year: 2011

Type: article

Abstract: On the right path: The mechanisms of endocytosis of cetuximab (C225) and its nanoconjugates have been elucidated in a pancreatic cancer cell line. By using gold nanoparticles as a scaffold, it is possible to switch the pathway for endocytosis from a Dyn-2-dependent caveolar mechanism to Cdc42-dependent pinocytosis/phagocytosis. Tailoring endocytotic mechanisms may enable specific intracellular pathways to be targeted.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201105432

Authors: Sanjib Bhattacharyya, Raman Deep Singh, Richard Pagano, J. David Robertson, Resham Bhattacharya, Priyabrata Mukherjee

Institutions: Mayo Clinic, University of Missouri

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute