Cytokine Genetic Variations and Fatigue Among Patients With Breast Cancer
Year: 2013
Type: article
Study design: Observational Study
Abstract: PURPOSE: Fatigue is a common adverse effect of cancer treatment and may persist for years after treatment completion. However, risk factors for post-treatment fatigue have not been determined. On the basis of studies suggesting an inflammatory basis for fatigue, this study tested the hypothesis that expression-regulating polymorphisms in proinflammatory cytokine genes would predict post-treatment fatigue in breast cancer survivors. PATIENTS AND METHODS: Women diagnosed with early-stage breast cancer (n = 171) completed questionnaires to assess fatigue and other behavioral symptoms (ie, depressive symptoms, memory complaints, sleep disturbance) and provided blood for genotyping within 3 months after primary treatment. Genomic DNA was extracted from peripheral-blood leukocytes and assayed for single nucleotide polymorphisms (SNPs) in the promoter regions of three cytokine genes: ILB -511 C>T (rs16944), IL6 -174 G>C (rs1800795), and TNF -308 G>A (rs1800629). An additive genetic risk score was computed by summing the number of high-expression alleles (zero, one, or two) across all three polymorphisms. RESULTS: The genetic risk index was significantly associated with fatigue; as the number of high-expression alleles increased, so did self-reported fatigue severity (P = .002). Analyses of individual SNPs showed that TNF -308 and IL6 -174 were independently associated with fatigue (P = .032). The genetic risk index was also associated with depressive symptoms (P = .007) and memory complaints (P = .016). CONCLUSION: These findings further implicate inflammatory processes as contributors to cancer-related fatigue and suggest a new strategy for identifying and treating patients at risk for this symptom based on genetic variants in proinflammatory cytokine genes.
Source: Journal of Clinical Oncology
Language: English
Topic: Cancer survivorship and care
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Aging: Sleep and Inflammatory Mechanisms in Depression Prevention, Social Isolation and Sleep Disturance in Aging: Inflammatory Mechanisms, Sleep, Inflamation, and Depression Occurrence in Breast Cancer Survivors, Cognitive Functioning After Breast Cancer Treatment, Combinatorial Genomics in Cancer, UCLA Older Americans Independence Center, Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune Mechanisms, Mechanisms of Sleep Disruption Hyperalgesia, Chronic Moderate Sleep Restriction in Older Long and Older Average Sleepers
OpenAlex ID: W2136796063