Work

Neurotransmitter Corelease: Mechanism and Physiological Role

Year: 2011

Type: review

Abstract: Neurotransmitter identity is a defining feature of all neurons because it constrains the type of information they convey, but many neurons release multiple transmitters. Although the physiological role for corelease has remained poorly understood, the vesicular uptake of one transmitter can regulate filling with the other by influencing expression of the H(+) electrochemical driving force. In addition, the sorting of vesicular neurotransmitter transporters and other synaptic vesicle proteins into different vesicle pools suggests the potential for distinct modes of release. Corelease thus serves multiple roles in synaptic transmission.

Source: Annual Review of Physiology

DOI: 10.1146/annurev-physiol-020911-153315

Authors: Thomas S. Hnasko, Robert H. Edwards

Institution: University of California, San Francisco

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Institute of Mental Health, National Institute on Drug Abuse

Awards: Transport of Neurotransmitter Into Synaptic Vesicles, Genetic Elucidation of VTA Glutamate Neurons