Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity
Year: 1998
Type: article
Abstract: Long-term neuronal plasticity is known to be dependent on rapid de novo synthesis of mRNA and protein, and recent studies provide insight into the molecules involved in this response. Here, we demonstrate that mRNA encoding a member of the regulator of G-protein signaling (RGS) family, RGS2, is rapidly induced in neurons of the hippocampus, cortex, and striatum in response to stimuli that evoke plasticity. Although several members of the RGS family are expressed in brain with discrete neuronal localizations, RGS2 appears unique in that its expression is dynamically responsive to neuronal activity. In biochemical assays, RGS2 stimulates the GTPase activity of the alpha subunit of Gq and Gi1. The effect on Gi1 was observed only after reconstitution of the protein in phospholipid vesicles containing M2 muscarinic acetylcholine receptors. RGS2 also inhibits both Gq- and Gi-dependent responses in transfected cells. These studies suggest a novel mechanism linking neuronal activity and signal transduction.
Source: Journal of Neuroscience
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Awards: REGULATION OF CYCLIC NUCLEOTIDE METABOLISM, NOVEL CELLULAR MECHANISMS IN CORTEX DEVELOPMENT, Arc and synaptic plasticity, TRANSCRIPTION FACTOR GENES,NEURONAL PLASTICITY AND AGING, G Protein-Coupled Receptors -- Structure and Regulation, Regulation of Cyclic Nucleotide Metabolism, G PROTEIN-COUPLED RECEPTORS--STRUCTURE AND REGULATION, G9000072466, G976133492
OpenAlex ID: W2136972830