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Problems with the transorientation hypothesis

Year: 2002
Type: article
Abstract: A novel mechanism for the very first step in polypeptide elongation on the ribosome has recently been proposed by Simonson and Lake (2002). According to their transorientation hypothesis, the incoming aminoacyl-transfer RNA (aa-tRNA) initially binds to the messenger RNA (mRNA) with the anticodon stacked on the 5′ side of the anticodon loop; then, following GTP hydrolysis, the tRNA swings into the A-site by switching from the 5′-stacked conformation to the classic 3′-stacked geometry while maintaining Watson–Crick base pairing with the mRNA. There are several serious problems with this proposal.
Source: RNA
DOI: 10.1017/s1355838202027061
Institutions: University of Alabama at Birmingham, New York State Department of Health, Wadsworth Center, Howard Hughes Medical Institute, State University of New York, University at Albany, State University of New York
Language: English
Open Access status: bronze
Awards: STRUCTURAL ANALYSIS OF MACROMOLECULAR ASSEMBLY, Structural Aspects of Protein Synthesis in the Mammalian Mitochondria, G572949972, G6954297294, STRUCTURE OF RIBONUCLEIC ACIDS, G9000014357
OpenAlex ID: W2137085237
FWCI: 0.116
Cites: 8
Cited by: 4
Related to: 10