Work

Are hypertrophic astrocytes a sufficient criterion of perinatal telencephalic leucoencephalopathy?

Year: 1973

Type: article

Abstract: To determine if the presence of amphophilic globules (GL) in infant cerebral white matter was a necessary criterion of perinatal telencephalic leucoencephalopathy (PTL), the epidemiological features of infants who had PTL-that is, hypertrophic astrocytes and amphophilic globules (HA·GL)-in their cerebral white matter were compared with those of infants who had hypertrophic astrocytes, but who did not have amphophilic globules (HA·[unk]). Postmortem bacteraemia was seen much more frequently in infants with HA·GL than in infants with HA·[unk] (P<0·05). In addition, infants with HA·GL tended to die at older postnatal ages than infants with HA·[unk]. These observations are in keeping with the view that HA·GL and HA·[unk] are not epidemiologically identical. The operational definition of PTL therefore remains the occurrence of both HA and GL in infant cerebral white matter.

Source: Journal of Neurology Neurosurgery & Psychiatry

DOI: 10.1136/jnnp.36.3.383

Authors: A. Leviton, F. H. Gilles

Institutions: Boston Children's Hospital, Harvard University

Language: English

Topic: Neonatal and fetal brain pathology

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2137115622