Work

The JARID2–PRC2 duality: Figure 1.

Year: 2010

Type: preprint

Abstract: Polycomb group proteins (PcG) are required for proper developmental regulation and cell fate commitment in metazoans. Recently, four studies reported the identification of JARID2, a JmjC domain-containing protein, as a component of the Polycomb-repressive complex 2 (PRC2), which is involved in implementing histone H3 Lys 27 methylation and transcriptional repression during development. Here, we discuss the implications of these studies for an improved understanding of PcG function in development.

Source: Genes & Development

DOI: 10.1101/gad.1921610

Authors: Hans-Martin Herz, Ali Shilatifard

Institution: Stowers Institute for Medical Research

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: Jane Coffin Childs Memorial Fund for Medical Research, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: G2069389452, G3369446003, G4498838370, G6224221772, G9000171076, G9000180485, G9000342474

OpenAlex ID: W2137152152

Cites: 51

Cited by: 62

Related to: 10