The Effect of Major Depression on Subjective and Objective Cognitive Deficits in Mild to Moderate Traumatic Brain Injury
Year: 2006
Type: article
Study design: Observational Study
Abstract: The effect of major depression on subjective and objective cognitive deficits 6 months following mild to moderate traumatic brain injury (TBI) was assessed in 63 subjects. Patients with subjective cognitive complaints (n=63) were more likely to be women, with higher Glasgow Coma Scale (GCS) scores and have a diagnosis of major depression. They also performed significantly more poorly on various measures of memory, attention and executive functioning. Group differences on most but not all cognitive measures disappeared in a multivariate analysis when controlling for depression. In mild to moderate TBI, subjective cognitive deficits are linked in large measure to comorbid major depression. However, other mechanisms may also account for these deficits.
Source: Journal of Neuropsychiatry
Authors: Laury Chamelian, Anthony Feinstein
Institutions: Sunnybrook Health Science Centre, University of Toronto
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2137174078