Work

Synthesis of fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides

Year: 2010

Type: article

Abstract: gem-Difluoro-1,7-enyne amides are suitable building blocks for the synthesis of difluorodihydropyridinones via a ring-closing metathesis reaction, and of 4,4-difluoro-3-oxoisoquinolines through a ring-closing metathesis-enyne metathesis tandem reaction. These products, in turn, undergo a Diels-Alder reaction to yield heterotricyclic systems in moderate to good yields.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.6.48

Authors: Satoru Arimitsu, Gerald B Hammond

Institutions: Kyoto University, University of Louisville

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: diamond

Funders: National Science Foundation, Division of Chemistry

Award: Alkynylogation and transformative fluorination in synthesis