Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe)
Year: 2011
Type: review
Study design: Observational Study
Abstract: Height is a complex trait under strong genetic influence. To date, numerous genetic loci have been associated with height in individuals of European ancestry. However, few large-scale discovery genome-wide association studies (GWAS) of height in minority populations have been conducted and thus information about population-specific height regulation is limited. We conducted a GWA analysis of height in 8149 African-American (AA) women from the Women's Health Initiative. Genetic variants with P< 5 × 10(-5) (n = 169) were followed up in a replication data set (n = 20 809) and meta-analyzed in a total of 28 958 AAs and African-descent individuals. Twelve single-nucleotide polymorphisms (SNPs) representing 7 independent loci were significantly associated with height at P < 5 × 10(-8). We identified novel SNPs in 17q23 (TMEM100/PCTP) and Xp22.3 (ARSE) reflecting population-specific regulation of height in AAs and replicated five loci previously reported in European-descent populations [4p15/LCORL, 11q13/SERPINH1, 12q14/HMGA2, 17q23/MAP3K3 (mitogen-activated protein kinase3) and 18q21/DYM]. In addition, we performed an admixture mapping analysis of height which is both complementary and supportive to the GWA analysis and suggests potential associations between ancestry and height on chromosomes 4 (4q21), 15 (15q26) and 17 (17q23). Our findings provide insight into the genetic architecture of height and support the investigation of non-European-descent populations for identifying genetic factors associated with complex traits. Specifically, we identify new loci that may reflect population-specific regulation of height and report several known height loci that are important in determining height in African-descent populations.
Source: Human Molecular Genetics
DOI: 10.1093/hmg/ddr489
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Awards: G109231058, G1107292973, G156924709, G1593340546, G1617453120, G1646017446, G206718646, G2253702613, G2286437695, G2295046671, G2417273319, G2547046739, G257474614, G2852769941, G2868073770, G3544793024, G3642616392, G4214622172, G4216744017, G4281851297, COORDINATING CENTER FOR WOMEN'S HEALTH INITIATIVE, G4321061599, G443405440, G4454202622, G4484576498, G4560602636, G484043965, G4847987001, G4940723635, G5026349245, G5183277930, G5209003178, G530368906, G532295152, G555506801, G5881391427, G603760282, G6464247198, G6604908402, G7066869570, G7071300326, G7272550893, G7323080267, G7582705761, G8178424689, G8399797517, G8750984004, G8780700017, G8934942062, G9000072420, Cancer Center Support Grant, G999174792
OpenAlex ID: W2137397266