ESC Working Group Cellular Biology of the Heart: Position Paper: improving the preclinical assessment of novel cardioprotective therapies
Year: 2014
Type: article
Abstract: Ischaemic heart disease (IHD) remains the leading cause of death and disability worldwide. As a result, novel therapies are still needed to protect the heart from the detrimental effects of acute ischaemia-reperfusion injury, in order to improve clinical outcomes in IHD patients. In this regard, although a large number of novel cardioprotective therapies discovered in the research laboratory have been investigated in the clinical setting, only a few of these have been demonstrated to improve clinical outcomes. One potential reason for this lack of success may have been the failure to thoroughly assess the cardioprotective efficacy of these novel therapies in suitably designed preclinical experimental animal models. Therefore, the aim of this Position Paper by the European Society of Cardiology Working Group Cellular Biology of the Heart is to provide recommendations for improving the preclinical assessment of novel cardioprotective therapies discovered in the research laboratory, with the aim of increasing the likelihood of success in translating these new treatments into improved clinical outcomes.
Source: Cardiovascular Research
DOI: 10.1093/cvr/cvu225
Institutions: University of Cape Town, Aarhus University Hospital, National Research Council, University College London, Universitat Autònoma de Barcelona, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Friedrich-Alexander-Universität Erlangen-Nürnberg, Semmelweis University, Pharmahungary Group (Hungary), Essen University Hospital, West German Heart and Vascular Center Essen, University of Chieti-Pescara, Lyon 1 Université, Inserm, Hospices Civils de Lyon, Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition, Justus-Liebig-Universität Gießen, University Medical Center Utrecht, Hubrecht Institute for Developmental Biology and Stem Cell Research
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,329
OpenAlex ID: W2137442910