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Protection of Mice againstPlasmodium yoeliiSporozoite Challenge withP. yoeliiMerozoite Surface Protein 1 DNA Vaccines

Year: 1998

Type: article

Abstract: Immunization of mice with DNA vaccines encoding the full-length form and C and N termini of Plasmodium yoelii merozoite surface protein 1 provided partial protection against sporozoite challenge and resulted in boosting of antibody titers after challenge. In C57BL/6 mice, two DNA vaccines provided protection comparable to that of recombinant protein consisting of the C terminus in Freund's adjuvant.

Source: Infection and Immunity

DOI: 10.1128/iai.66.7.3457-3461.1998

Authors: Sylvia I. Becker, Ruobing Wang, Richard C. Hedstrom, Joao C. Aguiar, Trevor R. Jones, Stephen L. Hoffman, Malcolm J. Gardner

Institutions: Naval Medical Research Command, World Health Organization Regional Office for the Americas, University of Maryland, Baltimore

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2137569742

FWCI: 6.483

Cites: 25

Cited by: 41

Related to: 10