Work

Glutamine‐fueled mitochondrial metabolism is decoupled from glycolysis in melanoma

Year: 2012

Type: review

Abstract: In this perspective, we revise the historic notion that cancer is a disease of mitochondria. We summarize recent findings on the function and rewiring of central carbon metabolism in melanoma. Metabolic profiling studies using stable isotope tracers show that glycolysis is decoupled from the tricarboxylic acid (TCA) cycle. This decoupling is not 'dysfunction' but rather an alternate wiring required by tumor cells to remain metabolically versatile. In large part, this requirement is met by glutamine feeding the TCA cycle as an alternative source of carbon. Glutamine is also used in non-conventional ways, like traveling in reverse through the TCA flux to feed fatty acid biosynthesis. Biosynthetic networks linked with non-essential amino acids alanine, serine, arginine, and proline are also significantly impacted by the use of glutamine as an alternate carbon source.

Source: Pigment Cell & Melanoma Research

DOI: 10.1111/pcmr.12000

Authors: Fabian V. Filipp, Boris Ratnikov, Jessica De Ingeniis, Jeffrey W. Smith, Andrei L. Osterman, David A. Scott

Institutions: University of California, Merced, Sanford Burnham Prebys Medical Discovery Institute

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute