Work

Science to Practice: Versatile Method to Track Transplanted Encapsulated Islet Cells with Multiple Imaging Modalities

Year: 2010

Type: article

Abstract: Pancreatic islet transplantation may provide an effective therapy for patients with type I diabetes. By encapsulating islets in alginate capsules, their survival is substantially improved. Methods to monitor the distribution of the encapsulated islets during delivery and afterward would help to optimize this type of therapy. Barnett and coworkers (1) showed, for the first time, it is possible to visualize encapsulated islets by using magnetic resonance (MR) imaging, computed tomography (CT), and ultrasonography (US) after the inclusion of perfluorocarbon in the capsules. Importantly, it was shown that the therapeutic effect of the islets was sustained for more than 50 days when implanted into mice.

Source: Radiology

DOI: 10.1148/radiol.102011

Authors: David P. Cormode, Willem J. M. Mulder, Zahi A. Fayad

Institution: Icahn School of Medicine at Mount Sinai

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Biomedical Imaging and Bioengineering