Assessment of reproductive disorders and birth defects in communities near hazardous chemical sites. II. Female reproductive disorders
Year: 1997
Type: article
Abstract: Members of the workgroup on female reproductive disorders discussed methods to evaluate five principal functions: menstrual dysfunction, infertility, pregnancy loss, lactation disorders, and pregnancy complications. To test each function, a nested strategy was considered, based on progressive levels of effort available to conduct field investigations. This strategy was analogous to the three-tier classification of biomarkers used by other workshops. The lowest level of effort, corresponding to Tier 1, consists only of questionnaires, diaries, and reviews of maternal and infant medical records. The medium level of effort (Tier 2) collects data from questionnaires and diaries, and some biologic specimens. Suggested laboratory analyses included measurement of progesterone in saliva and several glycoprotein hormones in urine that evaluate menstrual dysfunction, infertility, and pregnancy loss. The highest level of effort (Tier 3) involves prospective collection of diary information and simultaneous collection of biological specimens.
Source: Reproductive Toxicology
Institutions: Georgetown University Medical Center, Department of Health Services, Agency for Toxic Substances and Disease Registry, National Institute of Environmental Health Sciences, Columbia University, University of California, Berkeley, National Institute for Occupational Safety and Health, University of Cincinnati, University of Massachusetts Chan Medical School, Centers for Disease Control and Prevention
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,800
OpenAlex ID: W2137649602