Work

Acoustic Droplet Vaporization and Propulsion of Perfluorocarbon‐Loaded Microbullets for Targeted Tissue Penetration and Deformation

Year: 2012

Type: article

Abstract: Bullets and rockets: Ultrasound-triggered vaporization of a perfluorocarbon compound loaded into microbullets provides the necessary force for the microbullets to penetrate, cleave, and deform cellular tissue for potential targeted drug delivery and precision nanosurgery. The microbullets have an inner Au layer that allows conjugation of a monolayer of thiolated cysteamine (green in picture) for electrostatic attachment of perfluorocarbon droplets (purple droplets).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201201902

Authors: Daniel Kagan, Michael J. Benchimol, Jonathan C. Claussen, Erdembileg Chuluun‐Erdene, Sadik Esener, Joseph Wang

Institution: University of California San Diego

Language: English

Topic: Ultrasound and Hyperthermia Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: U.S. Public Health Service, National Cancer Institute

Awards: Center of Nanotechnology for Treatment, Understanding, *, UCSD Cancer Nanotechnology Training Center, G6772576533