A Strategy To Advance the Evidence Base in Palliative Medicine: Formation of a Palliative Care Research Cooperative Group
Year: 2010
Type: article
Abstract: BACKGROUND: Palliative medicine has made rapid progress in establishing its scientific and clinical legitimacy, yet the evidence base to support clinical practice remains deficient in both the quantity and quality of published studies. Historically, the conduct of research in palliative care populations has been impeded by multiple barriers including health care system fragmentation, small number and size of potential sites for recruitment, vulnerability of the population, perceptions of inappropriateness, ethical concerns, and gate-keeping. METHODS: A group of experienced investigators with backgrounds in palliative care research convened to consider developing a research cooperative group as a mechanism for generating high-quality evidence on prioritized, clinically relevant topics in palliative care. RESULTS: The resulting Palliative Care Research Cooperative (PCRC) agreed on a set of core principles: active, interdisciplinary membership; commitment to shared research purposes; heterogeneity of participating sites; development of research capacity in participating sites; standardization of methodologies, such as consenting and data collection/management; agile response to research requests from government, industry, and investigators; focus on translation; education and training of future palliative care researchers; actionable results that can inform clinical practice and policy. Consensus was achieved on a first collaborative study, a randomized clinical trial of statin discontinuation versus continuation in patients with a prognosis of less than 6 months who are taking statins for primary or secondary prevention. This article describes the formation of the PCRC, highlighting processes and decisions taken to optimize the cooperative group's success.
Source: Journal of Palliative Medicine
Authors: Amy P. Abernethy, Noreen M. Aziz, Ethan Basch, Janet Bull, Charles S. Cleeland, David C. Currow, Diane Fairclough, Laura Hanson, Joshua Hauser, Danielle Ko, Linda Lloyd, R. Sean Morrison, Shirley Otis-Green, Steve Pantilat, Russell K. Portenoy, Christine Ritchie, Graeme Rocker, Jane L. Wheeler, S. Yousuf Zafar, Jean S. Kutner
Institutions: Duke Medical Center, National Institutes of Health, National Institute of Nursing Research, Memorial Sloan Kettering Cancer Center, Four Seasons, The University of Texas MD Anderson Cancer Center, Flinders University, Repatriation General Hospital, Colorado School of Public Health, University of North Carolina at Chapel Hill, Northwestern University, Massachusetts General Hospital, San Diego Hospice and The Institute for Palliative Medicine, Icahn School of Medicine at Mount Sinai, City Of Hope National Medical Center, University of California, San Francisco, Mount Sinai Beth Israel, University of Alabama at Birmingham, Dalhousie University, University of Colorado Denver
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2137875469