Associations of adiponectin with individual European ancestry in African Americans: the Jackson Heart Study

Year: 2014

Type: article

Abstract: BACKGROUND: Compared with European Americans, African Americans (AAs) exhibit lower levels of the cardio-metabolically protective adiponectin even after accounting for adiposity measures. Because few studies have examined in AA the association between adiponectin and genetic admixture, a dense panel of ancestry informative markers (AIMs) was used to estimate the individual proportions of European ancestry (PEA) for the AAs enrolled in a large community-based cohort, the Jackson Heart Study (JHS). We tested the hypothesis that plasma adiponectin and PEA are directly associated and assessed the interaction with a series of cardio-metabolic risk factors. METHODS: Plasma specimens from 1439 JHS participants were analyzed by ELISA for adiponectin levels. Using pseudo-ancestral population genotype data from the HapMap Consortium, PEA was estimated with a panel of up to 1447 genome-wide preselected AIMs by a maximum likelihood approach. Interaction assessment, stepwise linear and cubic multivariable-adjusted regression models were used to analyze the cross-sectional association between adiponectin and PEA. RESULTS: Among the study participants (62% women; mean age 48 ± 12 years), the median (interquartile range) of PEA was 15.8 (9.3)%. Body mass index (BMI) (p = 0.04) and insulin resistance (p = 0.0001) modified the association between adiponectin and PEA. Adiponectin was directly and linearly associated with PEA (β = 0.62 ± 0.28, p = 0.03) among non-obese (n = 673) and insulin sensitive participants (n = 1141; β = 0.74 ± 0.23, p = 0.001), but not among those obese or with insulin resistance. No threshold point effect was detected for non-obese participants. CONCLUSIONS: In a large AA population, the individual proportion of European ancestry was linearly and directly associated with plasma adiponectin among non-obese and non insulin-resistant participants, pointing to the interaction of genetic and metabolic factors influencing adiponectin levels.

Source: Frontiers in Genetics

DOI: 10.3389/fgene.2014.00022

Authors: Aurelian Bidulescu, Shweta Choudhry, Solomon K. Musani, Sarah G. Buxbaum, Jiankang Liu, Charles N. Rotimi, James G. Wilson, Herman A. Taylor, Gary H. Gibbons

Institutions: Indiana University Bloomington, Indiana University, University of California, San Francisco, University of Mississippi Medical Center, Jackson State University, National Institutes of Health, National Human Genome Research Institute, National Heart, Lung, and Blood Institute

Language: English

Topic: Adipokines, Inflammation, and Metabolic Diseases

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801

Funders: American Heart Association, Jackson State University, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Center on Minority Health and Health Disparities, National Center for Research Resources, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities

OpenAlex ID: W2137935756