Work

Synthesis of (2‐Arylindol‐3‐yl)acetamides as Probes of Mitochondrial Steroidogenesis—A New Mechanism for GABAA Receptor Modulation

Year: 1992

Type: article

Abstract: High affinity and selectivity for mitochondrial DBI receptors characterize indolylacetamides 1. These compounds stimulate the production of neurosteroids in glial cells allowing possible indirect modulation of the γ-aminobutyric acid receptor complex. In behavioral experiments with rats, 1a was found to have antineophobic action, that is, it reduces the fear of novelty.

Source: Angewandte Chemie International Edition in English

DOI: 10.1002/anie.199210601

Authors: Alan P. Kozikowski, Dawei Ma, Elena Romeo, James Auta, Vissilios Papadopoulos, Gulia Puia, Erminio Costa, Alessandro Guidotti

Institutions: Mayo Clinic in Florida, Georgetown University

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2138021256

FWCI:

Cites: 17

Cited by: 8

Related to: 10