Interaction between gas cooking andGSTM1null genotype in bronchial responsiveness: results from the European Community Respiratory Health Survey
Year: 2014
Type: article
Abstract: BACKGROUND: Increased bronchial responsiveness is characteristic of asthma. Gas cooking, which is a major indoor source of the highly oxidant nitrogen dioxide, has been associated with respiratory symptoms and reduced lung function. However, little is known about the effect of gas cooking on bronchial responsiveness and on how this relationship may be modified by variants in the genes GSTM1, GSTT1 and GSTP1, which influence antioxidant defences. METHODS: The study was performed in subjects with forced expiratory volume in one second at least 70% of predicted who took part in the multicentre European Community Respiratory Health Survey, had bronchial responsiveness assessed by methacholine challenge and had been genotyped for GSTM1, GSTT1 and GSTP1-rs1695. Information on the use of gas for cooking was obtained from interviewer-led questionnaires. Effect modification by genotype on the association between the use of gas for cooking and bronchial responsiveness was assessed within each participating country, and estimates combined using meta-analysis. RESULTS: Overall, gas cooking, as compared with cooking with electricity, was not associated with bronchial responsiveness (β=-0.08, 95% CI -0.40 to 0.25, p=0.648). However, GSTM1 significantly modified this effect (β for interaction=-0.75, 95% CI -1.16 to -0.33, p=4×10(-4)), with GSTM1 null subjects showing more responsiveness if they cooked with gas. No effect modification by GSTT1 or GSTP1-rs1695 genotypes was observed. CONCLUSIONS: Increased bronchial responsiveness was associated with gas cooking among subjects with the GSTM1 null genotype. This may reflect the oxidant effects on the bronchi of exposure to nitrogen dioxide.
Source: Thorax
Authors: André F S Amaral, Adaikalavan Ramasamy, Francesc Castro-Giner, Cosetta Minelli, Simone Accordini, Inga-Cecilie Sørheim, Isabelle Pin, Manolis Kogevinas, Rain Jõgi, David J Balding, Dan Norbäck, Giuseppe Verlato, Mario Olivieri, Nicole Probst-Hensch, Christer Janson, Jan-Paul Zock, Joachim Heinrich, Deborah L Jarvis
Institutions: MRC Centre for Environment and Health, Imperial College London, Centre for Human Genetics, University of Oxford, Center for Research in Environmental Epidemiology, University of Verona, University of Bergen, Inserm, Université Joseph Fourier, Centre Hospitalier Universitaire de Grenoble, Institut pour l'avancée des biosciences, Tartu University Hospital, University College London, Uppsala University, Azienda Ospedaliera Universitaria Integrata Verona, Swiss Tropical and Public Health Institute, University of Basel, Universitat Pompeu Fabra, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Helmholtz Munich
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,010
Funders: National Science Foundation, National Research Centre, Asthma and Lung UK, European Commission, Deutsche Forschungsgemeinschaft, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Eesti Teadusfondi, Fonds Wetenschappelijk Onderzoek, Sociedad Española de Neumología y Cirugía Torácica, Universiteit Antwerpen, Vlaamse regering, MRC-PHE Centre for Environment and Health, Medical Research Council, Instituto de Salud Carlos III, National Institute of Mental Health
OpenAlex ID: W2138326270