Work

Glutathione and Nitrosoglutathione in Macrophage Defense againstMycobacterium tuberculosis

Year: 2005

Type: article

Abstract: We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.

Source: Infection and Immunity

DOI: 10.1128/iai.73.3.1886-1889.2005

Authors: Vishwanath Venketaraman, Yaswant K. Dayaram, Meliza T. Talaue, Nancy D. Connell

Institution: Rutgers New Jersey Medical School

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, National Institute of Allergy and Infectious Diseases