Work

Ultrastructural Localization of the Herpes Simplex Virus Type 1 U L 31, U L 34, and U S 3 Proteins Suggests Specific Roles in Primary Envelopment and Egress of Nucleocapsids

Year: 2002

Type: article

Abstract: The wild-type UL31, UL34, and US3 proteins localized on nuclear membranes and perinuclear virions; the US3 protein was also on cytoplasmic membranes and extranuclear virions. The UL31 and UL34 proteins were not detected in extracellular virions. US3 deletion caused (i) virion accumulation in nuclear membrane invaginations, (ii) delayed virus production onset, and (iii) reduced peak virus titers. These data support the herpes simplex virus type 1 deenvelopment-reenvelopment model of virion egress and suggest that the US3 protein plays an important, but nonessential, role in the egress pathway.

Source: Journal of Virology

DOI: 10.1128/jvi.76.17.8939-8952.2002

Authors: Ashley E. Reynolds, Elizabeth G. Wills, Richard J. Roller, Brent J. Ryckman, Joel D. Baines

Institutions: Cornell University, University of Iowa

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases