Work

Absence of Amphotericin B-Tolerant Persister Cells in Biofilms of Some Candida Species

Year: 2008

Type: article

Abstract: Biofilms and planktonic cells of five Candida species were surveyed for the presence of persister (drug-tolerant) cell populations after exposure to amphotericin B. None of the planktonic cultures (exponential or stationary phase) contained persister cells. However, persisters were found in biofilms of one of two strains of Candida albicans tested and in biofilms of Candida krusei and Candida parapsilosis, but not in biofilms of Candida glabrata or Candida tropicalis. These results suggest that persister cells cannot solely account for drug resistance in Candida biofilms.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01473-07

Authors: Rawya S. Al-Dhaheri, L. Julia Douglas

Institution: University of Glasgow

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2138412094

FWCI: 6.771

Cites: 23

Cited by: 102

Related to: 10