Work

Genetic association of mating types and virulence in Cryptococcus neoformans

Year: 1992

Type: article

Abstract: A pair of congenic Cryptococcus neoformans var. neoformans strains, B-4476 (a mating type) and B-4500 (alpha mating type), that presumably differ only in mating type was constructed. This pair and their progeny, five alpha type and five a type, were tested for virulence in mice. In the parent strains as well as the progeny, alpha type was clearly more virulent than a type. In addition, death tended to occur earlier among the alpha-strain-infected mice that died than among the mice that died by infection caused by a strains. These data strongly suggest the genetic association of virulence with mating type in this human fungal pathogen.

Source: Infection and Immunity

DOI: 10.1128/iai.60.2.602-605.1992

Authors: K J Kwon-Chung, J C Edman, B L Wickes

Institution: National Institute of Allergy and Infectious Diseases

Language: English

Topic: Fungal Infections and Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases