Work

Synthesis and antibacterial evaluation of anziaic acid and its analogues as topoisomerase I inhibitors

Year: 2013

Type: article

Abstract: Naturally occurring anziaic acid was very recently reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity.

Source: MedChemComm

DOI: 10.1039/c3md00238a

Authors: Hao Lin, Thirunavukkarasu Annamalai, Priyanka Bansod, Yuk-Ching Tse-Dinh, Dianqing Sun

Institutions: University of Hawaii at Hilo, Florida International University

Language: English

Topic: Cancer therapeutics and mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Research Resources