Work

Proteomic Identification of a Direct Role for Cyclin D1 in DNA Damage Repair

Year: 2012

Type: review

Abstract: The human CCND1 gene, which encodes the cell-cycle protein cyclin D1, is one of the most frequently amplified genes in human cancers. Cyclin D1 activates the cyclin-dependent kinases CDK4 and CDK6 and drives cell proliferation. Beyond the cell-cycle role, the full repertoire of cyclin D1 functions in cancer cells is still unclear. Emerging evidence indicates that cyclin D1 may play a role in DNA damage response. In this review, we discuss observations linking cyclin D1 to DNA damage repair and summarize our recent findings, which show a cyclin D1 function in homologous recombination-mediated DNA repair.

Source: Cancer Research

DOI: 10.1158/0008-5472.can-11-3549

Authors: Siwanon Jirawatnotai, Yiduo Hu, David M. Livingston, Piotr Sicinski

Institutions: Harvard University, Mahidol University, Dana-Farber Cancer Institute

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute