Work

Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads

Year: 2010

Type: article

Abstract: In the past two decades, zebrafish genetic screens have identified a wealth of mutations that have been essential to the understanding of development and disease biology. More recently, chemical screens in zebrafish have identified small molecules that can modulate specific developmental and behavioural processes. Zebrafish are a unique vertebrate system in which to study chemical genetic systems, identify drug leads, and explore new applications for known drugs. Here, we discuss some of the advantages of using zebrafish in chemical biology, and describe some important and creative examples of small molecule screening, drug discovery and target identification.

Source: Cell Communication and Signaling

DOI: 10.1186/1478-811x-8-11

Authors: Kerrie L Taylor, Nicola J Grant, Nicholas D Temperley, E Elizabeth Patton

Institutions: Institute of Genetics and Cancer, MRC Human Genetics Unit, University of Edinburgh

Language: English

Topic: Zebrafish Biomedical Research Applications

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,390

Funders: National Alliance for Research on Schizophrenia and Depression, Wellcome Trust, Medical Research Scotland, European Commission