Work

The structure of monomeric components of self-assembling CXCR4 antagonists determines the architecture of resulting nanostructures

Year: 2011

Type: article

Abstract: Self-assembling peptides play increasingly important roles in the development of novel materials and drug delivery vehicles. Understanding mechanisms governing the assembly of nanoarchitectures is essential for the generation of peptide-based nanodevices. We find that a cone-shaped derivative of the second transmembrane domain of CXCR4 receptor, x4-2-6 self-assembles into nanospheres, while a related cylindrical peptide, x4-2-9 forms fibrils. Stronger intermolecular interactions in nanospheres than in fibrils result in slow rates of particle disassembly and protection against proteolytic degradation.

Source: Nanotechnology

DOI: 10.1088/0957-4484/22/50/505101

Authors: Youngshim Lee, Yuhong Chen, Nadya I Tarasova, Vadim Gaponenko

Institutions: University of Illinois Chicago, National Cancer Institute

Language: English

Topic: Supramolecular Self-Assembly in Materials

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute

Awards: G507424362, G7853962322, G9000173260