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Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection

Year: 2014
Type: article
Study design: Case Report
Abstract: BACKGROUND: A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. RESULTS: Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef. CONCLUSIONS: Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.
DOI: 10.1186/s12977-014-0069-9
Authors: Adam John Ritchie, Fangping Cai, Nicola MG Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S Abdool Karim, Bette T Korber, Andrew J McMichael, Feng Gao, Nilu Goonetilleke
Institutions: University of Oxford, Duke University, MRC Weatherall Institute of Molecular Medicine, University of KwaZulu-Natal, Los Alamos National Laboratory, Jilin University, University of North Carolina at Chapel Hill
Language: English
Subfield: Virology
Open Access status: gold
Estimated APC paid: $2,890
Awards: G1101234072, (CHAVI) Center for HIV/AIDS Vaccine Immunology, G1324223937, G1808123841, G2026096560, (CHAVI) Center for HIV/AIDS Vaccine Immunology, G8320254048, G8673949279, G9000226269, G9000250626, Center for AIDS Research, G97119092, G980529913
OpenAlex ID: W2138706459
FWCI: 1.185
Cites: 45
Cited by: 32
Related to: 10