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Therapy for Latent HIV-1 Infection: The Role of Histone Deacetylase Inhibitors

Year: 2013
Type: review
Abstract: Persistence of HIV-1 in latently infected CD4(+) T-cells prevents eradication in HIV-infected treated patients. Latency is characterized by a reversible silencing of transcription of integrated HIV-1. Several molecular mechanisms have been described which contribute to latency, including the establishment and maintenance of repressive chromatin on the HIV-1 promoter. Histone deacetylation is a landmark modification associated with transcriptional repression of the HIV-1 promoter and inhibition of histone deacetylase enzymes (HDACs) reactivates latent HIV-1. Here, we review the different HDAC inhibitors that have been studied in HIV-1 latency and their therapeutic potential in reactivating latent HIV-1.
DOI: 10.3851/imp2551
Language: English
Subfield: Virology
Open Access status: bronze
Funders: National Institutes of Health, U.S. Public Health Service, Center for AIDS Research, University of Washington, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences
Awards: Novel Model for HIV Latency in Primary Memory T Cells, G1939027404, G2307004170, G2947119938, Innovative therapies to elimate persistent HIV Infection, North Carolina Translational & Clinical Sciences Institute (NC TraCS), Epigenetic regulation of HIV latency, G6041177408, Nanocrystal delivery to the CNS to improve HIV therapy, G7477205992, G7817696117, Martin Delaney Collaboratory to Eradicate HIV-1 Infection, The University of North Carolina Center for AIDS Research, HIV Latency, Epigenetics, and Therapeutics
OpenAlex ID: W2138753655
FWCI: 0.931
Cites: 55
Cited by: 47
Related to: 10