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Skeletons in the p53 tumor suppressor closet: genetic evidence that p53 blocks bone differentiation and development

Year: 2006

Type: article

Abstract: A series of in vitro tissue culture studies indicated that the p53 tumor suppressor promotes cellular differentiation, which could explain its role in preventing cancer. Quite surprisingly, however, two new in vivo studies provide genetic evidence that p53 blocks osteoblast differentiation and bone development. These interesting results and their biological and clinical implications are the focus of this comment.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.200601114

Authors: Gerard P. Zambetti, Edwin M. Horwitz, Ernestina Schipani

Institutions: St. Jude Children's Research Hospital, Harvard University, Massachusetts General Hospital

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2138837803

FWCI: 1.229

Cites: 11

Cited by: 37

Related to: 10