Work

A Highly Enantioselective Intramolecular Michael Reaction Catalyzed by N‐Heterocyclic Carbenes

Year: 2007

Type: article

Abstract: Metal-less Michael: A highly diastereo- and enantioselective intramolecular Michael addition of α,β-unsaturated aldehydes to enones catalyzed by an N-heterocyclic carbene (NHC) has been developed. The reaction is tolerant of alkyl and aromatic substituents, as well as saturated and unsaturated tethers between the enal and conjugate acceptor (see scheme).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200605235

Authors: Eric M. Phillips, Manabu Wadamoto, Audrey Chan, Karl A. Scheidt

Institution: Northwestern University

Language: English

Topic: N-Heterocyclic Carbenes in Organic and Inorganic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G344074598, G682315649