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In Vitro Activities of Posaconazole, Itraconazole, Voriconazole, Amphotericin B, and Fluconazole against 37 Clinical Isolates of Zygomycetes

Year: 2002

Type: article

Abstract: In vitro antifungal susceptibility testing results of a new antifungal triazole, posaconazole (POS), were compared to results with amphotericin B (AMB), itraconazole (ITC), voriconazole (VRC), and fluconazole (FLC) against clinical agents of zygomycosis. The MICs of POS at which 50% and 90% of the isolates were inhibited were 0.25 and 4 microg/ml, respectively. POS was significantly more active than VRC and FLC and slightly more active than ITC. The results suggest that POS has significant potential for clinical development against the zygomycetes.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.46.5.1581-1582.2002

Authors: Qiu N. Sun, Annette W. Fothergill, Dora I. McCarthy, Michael G. Rinaldi, John R. Graybill

Institutions: The University of Texas at San Antonio Health Science Center, South Texas Veterans Health Care System

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2138937494

FWCI: 13.93

Cites: 16

Cited by: 365

Related to: 8