Nascent Endothelium Initiates Th2 Polarization of Asthma
Year: 2013
Type: article
Abstract: Asthma airway remodeling is linked to Th2 inflammation. Angiogenesis is a consistent feature of airway remodeling, but its contribution to pathophysiology remains unclear. We hypothesized that nascent endothelial cells in newly forming vessels are sufficient to initiate Th2-inflammation. Vascular endothelial (VE)-cadherin is a constitutively expressed endothelial cell adhesion molecule that is exposed in its monomer form on endothelial tip cells prior to adherens junction formation. Abs targeted to VE-cadherin monomers inhibit angiogenesis by blocking this adherens junction formation. In this study, VE-cadherin monomer Ab reduced angiogenesis in the lungs of the allergen-induced murine asthma model. Strikingly, Th2 responses including, IgE production, eosinophil infiltration of the airway, subepithelial fibrosis, mucus metaplasia, and airway-hyperreactivity were also attenuated by VE-cadherin blockade, via mechanisms that blunted endothelial IL-25 and proangiogenic progenitor cell thymic stromal lymphopoietin production. The results identify angiogenic responses in the origins of atopic inflammation.
Source: The Journal of Immunology
Institutions: Cleveland Clinic, Cleveland Clinic Research
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Asthma Inflammation Research, Case Western Reserve University/Cleveland Clinic CTSA (UL1), G2343364956, G3698465645, Pathobiology of Asthma, Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*, Redox Determinants of Severe Asthma, Clinical and Translational Science Collaborative of Cleveland, G980506753
OpenAlex ID: W2138984761