It Takes Two to Tango: Dual Inhibition of PI3K and MAPK in Rhabdomyosarcoma
Year: 2013
Type: article
Abstract: The PI3K/AKT/mTOR and RAS/RAF/MAPK pathways play essential roles in rhabdomyosarcoma. Singular targeting of each pathway is ineffective due to extensive cross-talk and compensatory feedback between these two pathways. Dual blockade with inhibitors of PI3K and MAPK in combination synergistically inhibits growth of rhabdomyosarcoma both in vitro and in vivo.
Source: Clinical Cancer Research
Authors: Arman Jahangiri, William A. Weiss
Institution: University of California, San Francisco
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: National Cancer Institute
Awards: G165941928, G2274177223, Medulloblastoma and Metastases, Biology and Therapy of High Risk Neuroblastoma, G334124358, Genetic network analysis of cancer targets, G4523242390, G5470173024, G5715996091, G5737349078, G5776172611, Optical Measurement of Fast Drug Kinetics in Tumor, Biophysical and molecular dialogue of glioma cells and the brain microenvironment, G6462969395, G8866181309, Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma
OpenAlex ID: W2139026706